oxytocin alleviates cisplatin-induced renal damage in rats

objective(s):the purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (cp)-induced renal damage in rats. materials and methods: fourteen adult sprague dawley rats, weighing 200 to 210, were administered by cisplatin (cp, 2 mg/kg/day) twice a week for five weeks. then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day) or ot                       (200 µg/kg/day) for five weeks. seven rats served as control group. at the end of the treatment period, animals were sacrificed and their kidneys were assessed histologically. in addition,            c-reactive protein (crp), tgf-β and akt expression were evaluated immunohistochemically. results:both tubules and glomeruli were found to be severely damaged with marked medullary tubulo-interstitial inflammation due to chronic cisplatin exposure, particularly in the saline-treated group (group 1) compared to control group. oxytocin treatment spared renal tissue significantly by suppressing crp and tgf-β, and enhancing akt expression. conclusion: we conclude that renal damage due to cisplatin toxicity was prevented to a great extent by the anti-inflammatory effect of oxytocin.